Here are some common situations and tricks  :

Operating system
Game Type 
Windows XP Windows 7 Windows 8/8.1 Windows 10
Browser game

Directx 7, Directx 8
 Native  Native  Native  Native
Directx 9        Native Native   Set GAME compatibility to windows 7  Native
Directx 9 + optional
Directx 11 features
 Native  Desactivate AA and any DX11 features   Set GAME compatibility to windows 7,
desactivate AA and any DX11 features
 Directx 11 only  Impossible  Unsupported  Unsupported  Native
Opengl  Unsupported  Unsupported  Unsupported  Unsupported
  • Native : you have no special action to do , do not force moss or game compatibility
  • Unsupported : your screenshots will be be black , I have no solution
  • Impossible : your game wont start anyway !
  • tricks : try to use the trick suggested

Special cases :

Laptop with discrete GPU : force Moss to attach to the integrated GPU (Intel one usually)

use the forum if you still have issues : https://nohope.eu/forum/